منابع مشابه
Experimental human cytomegalovirus latency in CD14+ monocytes.
CD14(+) monocytes are a reservoir for latent human cytomegalovirus, and virus replication is reactivated during their differentiation to macrophages or dendritic cells. It has not been clear whether the virus can establish latency upon direct infection of monocytes or whether it must first become quiescent in a progenitor cell that subsequently differentiates to generate a monocyte. We report t...
متن کاملHuman Embryonic Stem Cell Lines Model Experimental Human Cytomegalovirus Latency
Herpesviruses are highly successful pathogens that persist for the lifetime of their hosts primarily because of their ability to establish and maintain latent infections from which the virus is capable of productively reactivating. Human cytomegalovirus (HCMV), a betaherpesvirus, establishes latency in CD34(+) hematopoietic progenitor cells during natural infections in the body. Experimental in...
متن کاملSifting and Winnowing through Human Cytomegalovirus Lytic Replication and Latency
My love of nature began in the field, forest, and creek behindmy house where I spent my summer days catching butterflies, salamanders, minnows, and toads. In high school, the logic and irrefutability of geometry proofs turnedme into a rational thinker. College steered me towards molecular biology. Graduate school introducedme to the art of generating data. My mentor, Joyce Hamlin, and the great...
متن کاملMechanisms modulating immune clearance during human cytomegalovirus latency.
H erpesviruses pursue strategies to avoid immune detection and establish lifelong latency. Alphaherpesviruses, such as HSV-1, infect humans via keratinized epithelium and set up latency in sensory neurons, providing lifelong residence in an immune privileged site. In contrast, gammaherpesvirses and betaherpesviruses initiate a systemic infection and deal with the host immune response by elabora...
متن کاملEpigenetic Control of Cytomegalovirus Latency and Reactivation
Cytomegalovirus (CMV) gene expression is repressed in latency due to heterochromatinization of viral genomes. In murine CMV (MCMV) latently infected mice, viral genomes are bound to histones with heterochromatic modifications, to enzymes that mediate these modifications, and to adaptor proteins that may recruit co-repressor complexes. Kinetic analyses of repressor binding show that these repres...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Medical Microbiology and Immunology
سال: 2015
ISSN: 0300-8584,1432-1831
DOI: 10.1007/s00430-015-0401-6